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Help Advance Myopia Research - UK Clinical Study of Atropine Now Recruiting


Childhood myopia (short-sightedness) is becoming increasingly common around the world. While glasses and contact lenses can correct vision, researchers now understand that myopia is more than just a need for spectacles. Higher levels of myopia can increase the risk of serious eye conditions later in life, including retinal detachment and myopic macular degeneration.


Because of this, scientists and eye care specialists are working hard to better understand how to slow the progression of myopia during childhood.


Several clinical research studies are currently recruiting children in the UK, and families are being invited to take part.


These studies are being conducted by leading research teams at Aston University, Queen's University Belfast, and Moorfields Eye Hospital.


Participating in research like this helps improve treatments for children in the future and may also provide families with access to specialist monitoring and care during the study period.


The MODERATO Study – Investigating Low-Dose Atropine


One of the main studies currently recruiting is the MODERATO trial, sponsored by Ocus International. The study is investigating whether low-dose atropine eye drops can help slow the progression of myopia in children. The trial compares two concentrations of atropine drops with a placebo (no actual treatment) to understand how effective these treatments are.


Who may be eligible?


The research team are currently looking for children to take part in the trial, so if your child fits the below criteria, they would love to hear from you!


  • Are aged 3–17 years

  • Have a myopia prescription of at least −0.75 dioptres

  • Have astigmatism or anisometropia of 1.50D or less

  • Have not used myopia control treatments in the past 3 months

  • The trials are being conducted at Aston University — Birmingham, Queen's University Belfast — Belfast and Moorfields Eye Hospital — London.


Children in the study can continue wearing their usual single-vision glasses or contact lenses.


How long does the study last?


The study runs for two years, with six clinic visits:

  • Baseline

  • 3 months

  • 6 months

  • 12 months

  • 18 months

  • 24 months


Additional Myopia Studies


Researchers at Aston University are also recruiting children for two additional studies. When families enquire, the research team can help determine which study may be most suitable.


Orthokeratology (Ortho-K) Study


This study investigates overnight contact lenses designed to reshape the front of the eye during sleep.


Eligibility


  • Age 8–15 years

  • Prescription −0.50 to −4.50D

  • Astigmatism ≤1.00D


Myopia Spectacle Lens Study


This study evaluates special spectacle lenses designed to help slow myopia progression.


Eligibility

  • Age 6–12 years

  • Prescription −0.50 to −4.75D

  • No current myopia control treatment


Interested in Learning More?


If you think your child may be suitable, the research team would be happy to hear from you.


They will help determine whether your child may qualify and which study could be the best fit.


You can also learn more about the atropine trial here:https://www.ocus-inno.com/moderato-trial/


Taking part in research like this helps scientists better understand childhood myopia — and we hope help improve treatments for future generations.



 
 
 

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